ABOUT US

ABOUT US

Company Profile


Immorna, founded in 2019, is a globally leading clinical-stage biotechnology company dedicated to the development of coding RNA vaccines and therapeutics.


Leveraging our advanced messenger RNA (mRNA) and self-replicating RNA (srRNA) technology platforms, proprietary delivery system platforms, and AI-enabled drug discovery platforms, we have rapidly built a diverse and high-potential product pipeline. Our R&D achievements span multiple critical fields including infectious diseases, cancer, and autoimmune diseases, with several candidate products already advancing into clinical development stages in both the United States and China.


Immorna is committed to technological innovation. Through unique antigen structure design and our next-generation innate-silent srRNA (isRNA) technology, we can precisely regulate the protein expression levels, duration of expression, and innate immune activation of coding RNA vaccines and therapeutics, aiming to achieve superior immunogenicity and safety profiles. More importantly, our proprietary ready-to-use (RTU) thermostable delivery system significantly enhances the storage stability of RNA vaccines, holding the potential to overcome the limitations of ultra-cold chain logistics. This lays a solid foundation for future product accessibility and commercialization. 


Building on the vast prospects and validated success of coding RNA technology, we are vigorously advancing key projects including JCXH-105 (shingles vaccine), JCXH-108 (RSV vaccine), JCXH-211 (solid tumor therapy), and JCXH-213 (in vivo CAR therapy). We aim to fully realize the potential of coding RNA technology, striving to become a pioneer in leading industry development, bringing breakthrough medical advancements to patients worldwide, and improving human health.

 

Corporate Mission

Corporate Mission


To utilize next-generation mRNA platforms and innovative delivery technology to develop life-saving medicines for patients.

Development History


2019

2020

2021

2022

2023

2024

2025

  • June 2019

    Founded in Hangzhou and began operations in China.

  • March 2020

    Established CMC laboratory in Hangzhou.

  • August 2020

    Established a research and development center in Shanghai.

  • December 2021

    Built GMP factory/global team.

  • March 2022

    Obtained FDA IND approval to conduct a Phase I trial of JCXH-211 as a monotherapy administered via intratumoral injection in the United States.

  • November 2022

    Obtained IND approval for phase I intratumoral injection monotherapy of JCXH-211 in China.

  • January 2023

    Obtained FDA IND approval to conduct phase I trials of JCXH-105 shingles vaccine in the United States

  • July 2023

    Obtained PDA IND approva to conduct phase I trials of JCXH-107 quadrivalent influenza vaccine in the United States

  • June 2024

    Obtained IND approval to conduct phase I trials of JCXH-108 respiratory syncytial virus vaccine in the United States

  • July 2024

    Obtained IND approval for phase II trial of JCXH-105 shingles vaccine in the United States.

  • July 2024

    Obtained IND approval for initiating phase I/II trials of JCXH-211 intravenous monotherapy and combination therapy with an anti-PD-1 antibody therapy in the United States.

  • August 2024

    Signed a funding agreement with the Gates Foundation for the JCXH-108 respiratory syncytial virus vaccine

  • October 2024

    Completed Phase I trial of JCXH-211 intratumoral injection monotherapy

  • November 2024

    Obtained IND approval to conduct Phase I trial of JCXH-211 combination therapy with anti-PD-1 antibody intratumoral injection in China.

  • May 2025

    Obtained interim immunogenicity and safety data of JCXH-108 respiratory syncytial virus vaccine phase I trial in the United States.

  • June 2025

    Obtained IND approval to conduct phase I trial of JCXH-105 shingles vaccine in China.

Global Distribution


map
map

Research Triangle Park, NC

Hangzhou

Shanghai

Research Triangle Park, NC
Research Triangle Park, NC

The RTP site launched in early 2022. It is quickly becoming Immorna’s powerhouse of innovation and will drive development of new RNA modalities and delivery vehicles. This R&D center spearheads application of RNA platform technologies in new disease areas. The US site is also hub of Immorna’s global clinical development team.

Hangzhou
Hangzhou

In the heart of Zhejiang Province on the east coast of China, Hangzhou is the home of Immorna’s 70,000 sf CMC labs and offices. The city also houses Immorna’s 30,000 sf GMP pilot plant, which has the capability to manufacture investigational drugs and vaccines for large scale clinical trials. In addition, Immorna’s future commercial manufacturing plant is currently in development in Hangzhou.

上海
Shanghai

Sitting in the fast-growing biotech hotspot in Shanghai are Immorna’s state-of-the-art preclinical research labs, over 20,000 sf in size. This site drives the preclinical Proof-of-Concept studies for many programs in Immorna’s pipeline.

Company Team



Zihao Wang, PhD

Zihao Wang, PhD

CEO & Co-founder
Zhijun Guo, MBA

Zhijun Guo, MBA

CTO & Co-founder
Yuanqing Liu, MD, PhD

Yuanqing Liu, MD, PhD

CSO, China
NgocDiep Le, MD, PhD

NgocDiep Le, MD, PhD

President and Global CMO
Jeffrey Ulmer, PhD

Jeffrey Ulmer, PhD

CSA
Zhang Kexin, MS

Zhang Kexin, MS

Chief Strategy Officer, Secretary of the Borad
Marcin Bugno, PhD

Marcin Bugno, PhD

VP, RNA Development

Board of Directors


Zihao Wang, PhD

Zhijun Guo, MBA

Yuanqing Liu, MD, PhD

NgocDiep Le, MD, PhD

Jeffrey Ulmer, PhD

Zhang Kexin, MS

Marcin Bugno, PhD


Business license

Statement

SEO